I agree with dp that regular checks on the fasteners up there should be part of the general maintenance routine. I tend to stick a spanner on everything I can get at whenever I have the tank and seat off.
But I don't think there's a really big risk of a properly-screwed together 3/8th flange engine flying apart (with apologies to Trevinoz if his was well screwed together as well as well screwed on the road!). I have a feeling youthful indiscretion and throttle-happy enthusiasm coupled with hit and miss maintenance, non-existent finances and the usual sense of juvenile immortality were what made mine blow up.
All the same, the word on the block in those days was that you didn't want the thin flange barrels, just as you 'didn't want' an 8 stud Triumph. People didn't want dynamos either, as I recall, with the mag/alternator of the 60s Triumphs being quite the thing. (Mike hadn't made the DVR2 then, however!) And of course you 'didn't want' an A50 or A65 either, let alone, when they came out, an early Commando with the High Explosive Combat engine. Nor an early 750 Bonnie, because 'they all run their mains mate, usually just after the warranty runs out'. Above all else you 'didn't want' anything with more than one cylinder from AMC. Well, I've been breaking that bar-room rule for 35 years and have been very happy.
Such a fine line between myth and reality.
Apart from the one about 'japanese-crap' being fit for nothing, when it was a lot fitter for nearly everything than most of what it had to compete with. No fine line there.
And through it all the entire BMW range ticked along very nicely for them as could afford them. How perverse was it that when I eventually got my hands on a big Boxer, I promptly blew it up far more expensively than any British bike I had ever had . . . was that a case of reality flying in the face of a very positive myth? Don't know, but bought a K series instead, where myth and reality came together in harmony for well over 100,000 entirely hassle free miles.
Must get out more.